Arizona MPJE (Pharmacy Jurisprudence) Practice Exam

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A controlled substance with the combination of Difenoxin 1mg and Atropine 25mcg belongs to which schedule?

  1. CI

  2. CII

  3. CIV

  4. CV

The correct answer is: CI

The combination of Difenoxin 1mg and Atropine 25mcg is classified as a Schedule IV controlled substance under federal law. Schedule IV substances are considered to have a lower potential for abuse relative to substances in the higher schedules. Difenoxin, particularly in combination with atropine, is often used in anti-diarrheal formulations, and the low dose of atropine included is meant to discourage misuse—especially in forms that could otherwise lead to greater euphoric effects. This combination has been evaluated and determined to possess a lower potential for addiction and abuse compared to substances placed in Schedules I to III. Therefore, the correct answer is that the combination belongs to Schedule V, not Schedule I. Schedule I substances are those with a high potential for abuse and no accepted medical use, which does not apply in this case.

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